Anti-Ovine MHC Class II DR抗体[37.68] (ab34007)

概述

  • 产品名称Anti-Ovine MHC Class II DR抗体[37.68]
  • 描述
    小鼠单克隆抗体[37.68] to Ovine MHC Class II DR
  • 经测试应用适用于: Flow Cyt, IP, IHC-Frmore details
  • 种属反应性
    与反应: Sheep, Goat, Cow, Human
  • 免疫原

    Splenocytes from ATL mice

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified from tissue culture supernatant.
  • 克隆单克隆
  • 克隆编号37.68
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab34007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IP
IHC-Fr
  • 应用说明Flow Cyt: Use 1/50 - 1/200, or 10µl of the suggested working dilution to label 106 cells in 100µl.
    IHC-Fr: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Three subregions of the Major Histocompatibility Complex (MHC), DP, DQ and DR, determine class II molecules, which are essential in the cellular recognition interactions involved in the generation of an immune response. These molecules display processed antigens from virally-infected or transformed cells. Class-II-positive cells (antigen-presenting cells) can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes. Several class II antigens are also associated with disease states. The extremely high polymorphism of MHC class II transmembrane heterodimers is due to a few hypervariable segments present in the most external domain of their alpha and beta chains. The alpha chain of MHC-DR is not polymorphic, whereas the beta chain is highly so. Some changes in amino acid sequence are critical in disease susceptibility associations as well as the ability to present processed antigens to T cells.
    • 细胞定位Cell Membrane
    • 别名
      • DR alpha chain antibody
      • DR beta 5 antibody
      • HLA class II histocompatibility antigen antibody
      • HLA DRA antibody
      • HLA DRB1 antibody
      • MHC class II antigen DRA antibody
      see all

    Anti-Ovine MHC Class II DR antibody [37.68] (ab34007)参考文献

    ab34007 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"