Anti-OVCA1抗体(ab54777)

概述

  • 产品名称Anti-OVCA1抗体
    参阅全部 OVCA1 一抗
  • 描述
    小鼠单克隆抗体to OVCA1
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 216-325 of Human OVCA1

性能

应用

Our Abpromise guarantee covers the use of ab54777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 40 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival.
  • 组织特异性Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
  • 序列相似性Belongs to the DPH1/DPH2 family. DPH1 subfamily.
  • 细胞定位Nucleus. Cytoplasm. Punctate, primarily perinuclear localization.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Candidate tumor suppressor in ovarian cancer 1 antibody
    • Diphthamide biosynthesis protein 1 antibody
    • Diphthamide biosynthesis protein 2 homolog like 1 antibody
    • Diphthamide biosynthesis protein 2 homolog-like 1 antibody
    • Diphthamide biosynthesis protein 2 like antibody
    • Diphthamide biosynthesis protein 2-like antibody
    • Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 antibody
    • Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody
    • DPH like 1 (S. cerevisiae) antibody
    • DPH like 1 antibody
    • DPH-like 1 antibody
    • DPH1 antibody
    • DPH1 homolog (S. cerevisiae) antibody
    • DPH1 homolog antibody
    • DPH1_HUMAN antibody
    • DPH2 like 1 antibody
    • DPH2-like 1 antibody
    • DPH2L antibody
    • DPH2L1 antibody
    • FLJ33211 antibody
    • HsDph1 antibody
    • Ovarian cancer associated gene 1 antibody
    • Ovarian cancer associated gene 1 protein antibody
    • Ovarian cancer-associated gene 1 protein antibody
    • Ovarian tumor suppressor candidate 1 antibody
    see all

Anti-OVCA1 antibody 图像



  • Predicted band size : 40 kDa
    OVCA1 antibody (ab54777) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • ab54777 at 10 ug/ml staining OVCA1 in human Hela cells by Immunocytochemistry / Immunofluorescence.

Anti-OVCA1 antibody (ab54777)参考文献

ab54777 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Human Lymphocytes)
Specification Human Lymphocytes
Gel Running Conditions Reduced Denaturing (4-12%)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 20°C
Username

Abcam user community

Verified customer

提交于 May 23 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"