功能Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
组织特异性Widely expressed. Expressed at higher level in brain.
序列相似性Belongs to the peptidase C65 family. Contains 1 OTU domain.