概述

  • 产品名称Anti-OSTM1抗体
    参阅全部 OSTM1 一抗
  • 描述
    兔多克隆抗体to OSTM1
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen, corresponding to amino acids 225-278 (REAYKTLSSL YSEMQKMNEL ENKAEPGTHL CIDVEDAMNI TRKLWSRTFN CSVP) of Human OSTM1.

  • 阳性对照
    • Human liver tissue; Transfected HEK293T cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab121327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml.
WB 1/250 - 1/500.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Required for osteoclast and melanocyte maturation and function.
  • 疾病相关Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5) [MIM:259720]; also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chloride channel 7 beta subunit antibody
    • GAIP-interacting protein N terminus antibody
    • GIPN antibody
    • GL antibody
    • Grey lethal osteopetrosis antibody
    • HSPC019 antibody
    • OPTB5 antibody
    • Osteopetrosis-associated transmembrane protein 1 antibody
    • Ostm1 antibody
    • OSTM1_HUMAN antibody
    • OTTHUMP00000016938 antibody
    • OTTHUMP00000196342 antibody
    see all

Anti-OSTM1 antibody 图像

  • Immunocytochemistry/immunofluorescence analysis of A431 cells labelling OSTM1 with ab121327 shows positive staining in the nucleus, cytoplasm and vesicles.
  • All lanes : Anti-OSTM1 antibody (ab121327) at 1/250 dilution

    Lane 1 : Negative control (vector only transfected HEK293T lysate)
    Lane 2 : OSTM1-transfected HEK293T over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

    Developed using the ECL technique
  • ab121327, at 1/200, staining OSTM1 in paraffin embedded Human liver tissue by Immunohistochemistry.

Anti-OSTM1 antibody (ab121327)参考文献

ab121327 has not yet been referenced specifically in any publications.

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