Anti-Osteoprotegerin抗体(ab65934)

概述

  • 产品名称Anti-Osteoprotegerin抗体
    参阅全部 Osteoprotegerin 一抗
  • 描述
    兔多克隆抗体to Osteoprotegerin
  • 特异性Detects endogenous levels of total Osteoprotegerin protein.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide derived from internal sequence of human Osteoprotegerin

  • 阳性对照
    • Extracts from 293 cells

性能

应用

Our Abpromise guarantee covers the use of ab65934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: 1/10000.
    WB: 1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    • 组织特异性Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
    • 疾病相关Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.
    • 序列相似性Contains 2 death domains.
      Contains 4 TNFR-Cys repeats.
    • 翻译后修饰N-glycosylated. Contains sialic acid residues.
      The N-terminus is blocked.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC29565 antibody
      • OCIF antibody
      • OPG antibody
      • Osteoclastogenesis inhibitory factor antibody
      • Osteoprotegerin antibody
      • PDB5 antibody
      • TNF receptor superfamily member 11b antibody
      • TNFRSF 11B antibody
      • TNFRSF11B antibody
      • TR 1 antibody
      • TR1 antibody
      • TR11B_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 11B antibody
      see all

    Anti-Osteoprotegerin antibody 图像

    • All lanes : Anti-Osteoprotegerin antibody (ab65934) at 1/500 dilution

      Lane 1 : extracts from 293 cells
      Lane 2 : extracts from 293 cells with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 46 kDa
      Observed band size : 55 kDa (why is the actual band size different from the predicted?)

    Anti-Osteoprotegerin antibody (ab65934)参考文献

    ab65934 has not yet been referenced specifically in any publications.

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