概述

  • 产品名称Anti-Osteocalcin抗体
    参阅全部 Osteocalcin 一抗
  • 描述
    兔多克隆抗体to Osteocalcin
  • 特异性There were no cross reactivities obtained with human Osteopontin, human Osteonectin, and human Bone Sialoprotein.
  • 经测试应用适用于: WB, RIA, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Osteocalcin aa 1-22.
    Sequence:

    MRALTLLALLALAALCIAGQAG


    Database link: P02818

性能

应用

Our Abpromise guarantee covers the use of ab14173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. PubMed: 18760468
RIA 1/2000.
ELISA 1/5000.

靶标

  • 功能Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
  • 序列相似性Belongs to the osteocalcin/matrix Gla protein family.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • 翻译后修饰Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BGLAP antibody
    • BGP antibody
    • Bone gamma carboxyglutamate (gla) protein antibody
    • Bone gamma carboxyglutamate gla protein osteocalcin antibody
    • Bone gamma carboxyglutamate protein antibody
    • Bone Gla protein antibody
    • Gamma carboxyglutamic acid containing protein antibody
    • Gamma-carboxyglutamic acid-containing protein antibody
    • OC antibody
    • OCN antibody
    • OSTCN_HUMAN antibody
    • Osteocalcin antibody
    • OTTHUMP00000016586 antibody
    • PMF1 antibody
    see all

Anti-Osteocalcin antibody (ab14173)参考文献

This product has been referenced in:
  • Li C  et al. Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res 28:2094-108 (2013). Read more (PubMed: 23609180) »
  • Levi B  et al. Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells 29:1241-55 (2011). Read more (PubMed: 21656608) »

See all 5 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"