概述

  • 产品名称Anti-OSMR抗体
    参阅全部 OSMR 一抗
  • 描述
    兔多克隆抗体to OSMR
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Horse, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence 612-661 (

    LLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYH

    ) of Human OSMR, NP_003990.

  • 阳性对照
    • 721_B cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab85575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 111 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
  • 组织特异性Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.
  • 疾病相关Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 4 fibronectin type-III domains.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IL-31 receptor subunit beta antibody
    • IL-31R subunit beta antibody
    • IL-31R-beta antibody
    • IL-31RB antibody
    • Interleukin-31 receptor subunit beta antibody
    • MGC140467 antibody
    • MGC150626 antibody
    • MGC150627 antibody
    • MGC75127 antibody
    • Oncostatin M receptor antibody
    • Oncostatin M specific receptor subunit beta antibody
    • Oncostatin M-specific receptor, beta antibody
    • Oncostatin-M-specific receptor subunit beta antibody
    • Osmr antibody
    • OSMR_HUMAN antibody
    • OSMRB antibody
    see all

Anti-OSMR antibody 图像

  • Anti-OSMR antibody (ab85575) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 111 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
    Additional bands at : <40 kDa. We are unsure as to the identity of these extra bands.

Anti-OSMR antibody (ab85575)参考文献

ab85575 has not yet been referenced specifically in any publications.

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