概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-KHQLEETKKEKRTRIP
    • 氨基酸
      395 to 410

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-OSBP1 antibody (ab31107)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

常规信息

  • 别名
    • OSBP
    • OSBP 1
    • OSBP1_HUMAN
    • Oxysterol binding protein 1
    • Oxysterol-binding protein 1
    see all
  • 功能
    Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the OSBP family.
    Contains 1 PH domain.
  • 结构域
    The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
    The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
  • 细胞定位
    Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
  • Information by UniProt

OSBP1 peptide (395-410) (ab45716)参考文献

ab45716 has not yet been referenced specifically in any publications.

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