概述

  • 产品名称
  • 描述
    山羊多克隆抗体to OSBP1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit
  • 免疫原

    Synthetic peptide: CKEKQDWSSCPDIF, corresponding to C terminal amino acids 407-420 of Human OSBP1.

  • 常规说明
    GenBank Accession Number – NP_002547

性能

应用

Our Abpromise guarantee covers the use of ab5915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    Peptide ELISA: antibody detection limit dilution >1/16000
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 89.4 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
    • 组织特异性
      Widely expressed.
    • 序列相似性
      Belongs to the OSBP family.
      Contains 1 PH domain.
    • 结构域
      The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
      The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
    • 细胞定位
      Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • OSBP 1 antibody
      • OSBP antibody
      • OSBP1_HUMAN antibody
      • Oxysterol binding protein 1 antibody
      • Oxysterol-binding protein 1 antibody
      see all

    Anti-OSBP1 antibody 图像

    实验方案

    Anti-OSBP1 antibody (ab5915)参考文献

    ab5915 has not yet been referenced specifically in any publications.

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