概述

  • 产品名称Anti-ORMDL3抗体
    参阅全部 ORMDL3 一抗
  • 描述
    兔多克隆抗体to ORMDL3
  • 特异性ab107639 may cross-react with ORMDL1 and ORMDL2.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human ORMDL3 aa 53-81 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: Q8N138

  • 阳性对照
    • WB: Mouse testis tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab107639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 17 kDa.

靶标

  • 功能Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
  • 组织特异性Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
  • 疾病相关Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
  • 序列相似性Belongs to the ORM family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ORM1 (S. cerevisiae)-like 3 antibody
    • ORM1-like 3 (S. cerevisiae) antibody
    • ORM1-like 3 antibody
    • ORM1-like protein 3 antibody
    • ORMDL sphingolipid biosynthesis regulator 3 antibody
    • Ormdl3 antibody
    • ORML3_HUMAN antibody
    • OTTHUMP00000164334 antibody
    see all

Anti-ORMDL3 antibody 图像

  • All lanes : Anti-ORMDL3 antibody (ab107639) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Mouse testis lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

    Predicted band size : 17 kDa

    Blocking buffer 5% NFDM/TBST
    Diluting buffer  5% NFDM/TBST

Anti-ORMDL3 antibody (ab107639)参考文献

This product has been referenced in:
  • Zhuang LL  et al. Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene. PLoS One 8:e60630 (2013). WB ; Mouse . Read more (PubMed: 23577138) »

See 1 Publication for this product

Product Wall

Thank you for your reply and apologies for the mix up in my original response.

For both ab107639 and ab128660, we do guarantee that they will recognize the endogenous forms of the protein. For both antibodies, there are western blot images on ...

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Thank you for contacting Abcam.

If you wish a positive control to run in western blotting, then I would recommend the following GFP protein:

http://www.abcam.com/GFP-protein-ab84191.html.



If there is anything else I...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"