Anti-Orexin A抗体[MM0500-8G22] (ab89886)

概述

  • 产品名称
    Anti-Orexin A抗体[MM0500-8G22]
    参阅全部 Orexin A 一抗
  • 描述
    小鼠单克隆抗体[MM0500-8G22] to Orexin A
  • 经测试应用
    适用于: IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: PLPDCC RQK TCSCRLY EL LHGAGNHA A GILT, corresponding to amino acids 35-65 of Human Orexin A

性能

应用

Our Abpromise guarantee covers the use of ab89886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/50 - 1/100.

靶标

  • 相关性
    Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B (hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy.
  • 细胞定位
    Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
  • 数据库链接
  • 别名
    • HCRT antibody
    • HCRT1 antibody
    • HCRT2 antibody
    • hypocretin (orexin) neuropeptide precursor antibody
    • Hypocretin 1 antibody
    • Hypocretin 2 antibody
    • hypocretin antibody
    • NRCLP1 antibody
    • Orexin antibody
    • Orexin A antibody
    • Orexin B antibody
    • Orexin precursor antibody
    • OX antibody
    • PPORX antibody
    • PPOX antibody
    • PREPROOREXIN antibody
    see all

文献

ab89886 has not yet been referenced specifically in any publications.

客户评价及客户问答

Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
Methanol, 0.3%H2O2 as blocking agent for 20 minute(s) · Concentration: 0.3% · Temperature: 21°C
Antigen retrieval step
Enzymatic - Buffer/Enzyme Used: Proteinase K
Sample
Mouse Tissue sections (brain tissue, hypothalamus)
Specification
brain tissue, hypothalamus
Permeabilization
Yes - BSA
Fixative
Formaldehyde
Username

Mrs. Ingrid Hegeman

Verified customer

提交于 Feb 26 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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