Anti-Orexin A抗体(ab35337)
Key features and details
- Sheep polyclonal to Orexin A
- Suitable for: IHC-FoFr
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Orexin A抗体
参阅全部 Orexin A 一抗 -
描述
羊多克隆抗体to Orexin A -
宿主
Sheep -
经测试应用
适用于: IHC-FoFrmore details -
种属反应性
与反应: Human
预测可用于: Rat -
免疫原
Synthetic peptide corresponding to Human Orexin A aa 35-47 conjugated to Keyhole Limpet Haemocyanin (KLH). corresponding to amino acids 2-14 of human orexin A peptide
Sequence:NLPSTKVSWAAVT
Database link: O43612 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
Ammonium Sulfate fractionation. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab35337于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-FoFr |
Use at an assay dependent concentration.
|
说明 |
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IHC-FoFr
Use at an assay dependent concentration. |
靶标
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相关性
Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B (hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy. -
细胞定位
Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. -
数据库链接
- Entrez Gene: 3060 Human
- Entrez Gene: 25723 Rat
- Omim: 602358 Human
- SwissProt: O43612 Human
- SwissProt: O55232 Rat
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别名
- HCRT antibody
- HCRT1 antibody
- HCRT2 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab35337 被引用在 1 文献中.
- Silva JP et al. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature 462:646-50 (2009). IHC-FoFr ; Mouse . PubMed: 19956259