RabMAb

Anti-Orai1抗体[EPR3394(2)] (ab111960)

概述

  • 产品名称Anti-Orai1抗体[EPR3394(2)]
    参阅全部 Orai1 一抗
  • 描述
    兔单克隆抗体[EPR3394(2)] to Orai1
  • 经测试应用适用于: WBmore details
    不适用于: ICC,IHC-Fr,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to residues from Human Orai1.

  • 阳性对照
    • Human platelet lysate and Ovary cancer lysate.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab111960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 35,50 kDa (predicted molecular weight: 33 kDa).
  • 应用说明Is unsuitable for ICC,IHC-Fr,IHC-P or IP.
  • 靶标

    • 功能Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
    • 疾病相关Defects in ORAI1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) [MIM:612782]. IDTICED1 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhydrosis and non-progressive myopathy may be observed.
    • 序列相似性Belongs to the Orai family.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Calcium release activated calcium channel protein 1 antibody
      • Calcium release activated calcium modulator 1 antibody
      • Calcium release-activated calcium channel protein 1 antibody
      • CRACM 1 antibody
      • CRACM1 antibody
      • CRCM1 antibody
      • CRCM1_HUMAN antibody
      • FLJ14466 antibody
      • Orai 1 antibody
      • ORAI calcium release activated calcium modulator 1 antibody
      • orai1 antibody
      • ORAT1 antibody
      • Protein orai 1 antibody
      • Protein orai-1 antibody
      • TMEM 142A antibody
      • TMEM142A antibody
      • Transmembrane protein 142A antibody
      see all

    Anti-Orai1 antibody [EPR3394(2)] 图像

    • All lanes : Anti-Orai1 antibody [EPR3394(2)] (ab111960) at 1/1000 dilution

      Lane 1 : Human platelet lysate
      Lane 2 : Human ovary cancer lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 33 kDa

    Anti-Orai1 antibody [EPR3394(2)] (ab111960)参考文献

    This product has been referenced in:
    • Zhu M  et al. Store-operated Ca(2+) entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation. J Exp Clin Cancer Res 33:98 (2014). Read more (PubMed: 25433371) »

    See 1 Publication for this product

    Product Wall

    The concentration of lot GR100052 is 0.509 mg/ml.

    Thank you for contacting us and your interest in our products. I am pleased to provide the following immunogen information: In order to aid your research we are happy to provide this information to you. However, this immunogen sequence is propr...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"