概述

  • 产品名称Anti-Orai1抗体
    参阅全部 Orai1 一抗
  • 描述
    山羊多克隆抗体to Orai1
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide conjugated to KLH derived from the C terminal of Human Orai1.

  • 阳性对照
    • Human Spleen tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab110941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/32000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
  • 疾病相关Defects in ORAI1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) [MIM:612782]. IDTICED1 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhydrosis and non-progressive myopathy may be observed.
  • 序列相似性Belongs to the Orai family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Calcium release activated calcium channel protein 1 antibody
    • Calcium release activated calcium modulator 1 antibody
    • Calcium release-activated calcium channel protein 1 antibody
    • CRACM 1 antibody
    • CRACM1 antibody
    • CRCM1 antibody
    • CRCM1_HUMAN antibody
    • FLJ14466 antibody
    • Orai 1 antibody
    • ORAI calcium release activated calcium modulator 1 antibody
    • orai1 antibody
    • ORAT1 antibody
    • Protein orai 1 antibody
    • Protein orai-1 antibody
    • TMEM 142A antibody
    • TMEM142A antibody
    • Transmembrane protein 142A antibody
    see all

Anti-Orai1 antibody 图像

  • ab110941, at 3.75µg/ml, staining Orai1 in formalin-fixed, paraffin-embedded Human Spleen tissue by Immunohistochemistry.

Anti-Orai1 antibody (ab110941)参考文献

ab110941 has not yet been referenced specifically in any publications.

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