概述

  • 产品名称Anti-Opn1mw抗体
    参阅全部 Opn1mw 一抗
  • 描述
    兔多克隆抗体to Opn1mw
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 30-80 of Human Opn1mw, conjugated to KLH.

  • 阳性对照
    • HepG2 cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab104302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

靶标

  • 功能Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
  • 组织特异性The three color pigments are found in the cone photoreceptor cells.
  • 疾病相关Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD) [MIM:303800]; also known as deuteranopia.
    Defects in OPN1MW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia.
    Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5) [MIM:303700]. A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • 翻译后修饰Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CBBM antibody
    • CBD antibody
    • COD5 antibody
    • Color blindness, deutan antibody
    • Cone dystrophy 5 (X linked) antibody
    • GCP antibody
    • GOP antibody
    • Green cone photoreceptor pigment antibody
    • Green cone pigment antibody
    • Green sensitive opsin antibody
    • Green-sensitive opsin antibody
    • Medium wave sensitive antibody
    • Medium wave sensitive opsin 1 antibody
    • Medium-wave-sensitive opsin 1 antibody
    • MGC176615 antibody
    • MGC177321 antibody
    • MGC198468 antibody
    • MGC198469 antibody
    • OPN1MW antibody
    • OPN1MW1 antibody
    • OPN1MW2 antibody
    • OPSG_HUMAN antibody
    • Opsin 1 (cone pigments), medium wave sensitive (color blindness, deutan) antibody
    • Opsin 1 (cone pigments), medium wave sensitive 2 antibody
    • Opsin 1 (cone pigments), medium wave sensitive antibody
    • Photopigment apoprotein antibody
    see all

Anti-Opn1mw antibody 图像

  • Anti-Opn1mw antibody (ab104302) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 41 kDa

Anti-Opn1mw antibody (ab104302)参考文献

ab104302 has not yet been referenced specifically in any publications.

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