Anti-OGT / O-Linked N-Acetylglucosamine Transferase抗体(ab50270)


  • 产品名称
    Anti-OGT / O-Linked N-Acetylglucosamine Transferase抗体
    参阅全部 OGT / O-Linked N-Acetylglucosamine Transferase 一抗
  • 描述
    兔多克隆抗体to OGT / O-Linked N-Acetylglucosamine Transferase
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Pig
  • 免疫原

    Synthetic peptide:


    conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 1024-1037 of Human O-Linked N-Acetylglucosamine

  • 阳性对照
    • HeLa cell nuclear extract and A549 human lung carcinoma cells.



Our Abpromise guarantee covers the use of ab50270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 110 kDa (predicted molecular weight: 117 kDa).
ICC/IF 1/50 - 1/100. (Cells fixed with paraformaldehyde/triton).


  • 功能
    Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5 and HCFC1. Promotes proteolytic maturation of HCFC1.
  • 组织特异性
    Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
  • 通路
    Protein modification; protein glycosylation.
  • 序列相似性
    Belongs to the O-GlcNAc transferase family.
    Contains 13 TPR repeats.
  • 结构域
    The TPR repeat domain mediates recognition of protein substrates.
  • 翻译后修饰
    Ubiquitinated, leading to its proteasomal degradation.
  • 细胞定位
    Cytoplasm. Nucleus. Mostly in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ23071 antibody
    • GlcNAc transferase antibody
    • HRNT1 antibody
    • MGC22921 antibody
    • O GlcNAc antibody
    • O GlcNAc transferase p110 subunit antibody
    • O GlcNAc transferase subunit p110 antibody
    • O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase) antibody
    • O linked N acetylglucosamine (GlcNAc) transferase antibody
    • O linked N acetylglucosamine transferase 110 kDa subunit antibody
    • O-GlcNAc transferase subunit p110 antibody
    • O-linked N-acetylglucosamine transferase 110 kDa subunit antibody
    • ogt antibody
    • OGT1_HUMAN antibody
    • UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit antibody
    • UDP N acetylglucosamine peptide N acetylglucosaminyltransferase GlcNAc transferase antibody
    • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit antibody
    • UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase antibody
    • Uridinediphospho N acetylglucosamine:polypeptide beta N acetylglucosaminyl transferase antibody
    see all

Anti-OGT / O-Linked N-Acetylglucosamine Transferase antibody 图像

  • Cytoplasmic, and nuclear localization of O-Linked N-Acetylglucosamine in human lung carcinoma (A549) cells stained by ab50270. A. Working dilution of 1:100 B. Working dilution of 1:50

Anti-OGT / O-Linked N-Acetylglucosamine Transferase antibody (ab50270)参考文献

This product has been referenced in:
  • Runager K  et al. Targeting O-glycosyltransferase (OGT) to promote healing of diabetic skin wounds. J Biol Chem 289:5462-6 (2014). WB ; Human . Read more (PubMed: 24398691) »
  • Rogacka D  et al. Expression of GFAT1 and OGT in podocytes: transport of glucosamine and the implications for glucose uptake into these cells. J Cell Physiol 225:577-84 (2010). WB, ICC/IF ; Rat . Read more (PubMed: 20506529) »

See all 2 Publications for this product

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