概述

  • 产品名称Anti-OFD1抗体
  • 描述
    兔多克隆抗体to OFD1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 2-51 (AQSTMPHKCD DVLSQDELRK KLYQTFKDRG ILDTLKTQLR NQLVHELMHP) of Rat OFD1 (NP_001100431).

  • 阳性对照
    • Rat liver lysate.

性能

应用

Our Abpromise guarantee covers the use of ab122960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 118 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation.
  • 组织特异性Widely expressed. Expressed in 9 and 14 weeks old embryos in metanephric mesenchyme, oral mucosa, lung, heart, nasal and cranial cartilage, and brain. Expressed in metanephros, brain, tongue, and limb.
  • 疾病相关Orofaciodigital syndrome 1
    Simpson-Golabi-Behmel syndrome 2
    Joubert syndrome 10
    Retinitis pigmentosa 23
  • 序列相似性Belongs to the OFD1 family.
    Contains 1 LisH domain.
  • 细胞定位Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310).
  • Information by UniProt
  • 数据库链接
  • 别名
    • 71 7A antibody
    • 717A antibody
    • CXorf5 antibody
    • JBTS10 antibody
    • Ofd1 antibody
    • OFD1_HUMAN antibody
    • oral facial digital syndrome 1 antibody
    • Oral-facial-digital syndrome 1 protein antibody
    • OTTHUMP00000022941 antibody
    • Protein 71-7A antibody
    • RGD1562231 antibody
    • SGBS2 antibody
    see all

Anti-OFD1 antibody 图像

  • Anti-OFD1 antibody (ab122960) at 1 µg/ml + Rat liver lysate at 10 µg

    Predicted band size : 118 kDa

Anti-OFD1 antibody (ab122960)参考文献

ab122960 has not yet been referenced specifically in any publications.

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