概述

  • 产品名称Anti-OBSCN抗体
    参阅全部 OBSCN 一抗
  • 描述
    兔多克隆抗体to OBSCN
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 4984-5126 of Human OBSCN.

  • 阳性对照
    • Human skeletal muscle tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 DH (DBL-homology) domain.
    Contains 3 fibronectin type-III domains.
    Contains 55 Ig-like (immunoglobulin-like) domains.
    Contains 1 IQ domain.
    Contains 2 PH domains.
    Contains 2 protein kinase domains.
    Contains 1 SH3 domain.
  • 细胞定位Cytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BC046431 antibody
    • Gm878 antibody
    • KIAA1556 antibody
    • KIAA1639 antibody
    • OBSCN antibody
    • OBSCN_HUMAN antibody
    • Obscurin antibody
    • Obscurin-MLCK antibody
    • Obscurin-myosin light chain kinase antibody
    • Obscurin-RhoGEF antibody
    • OTTMUSG00000005786 antibody
    • UNC89 antibody
    see all

Anti-OBSCN antibody 图像

  • ab121652, at 1/3500 dilution, staining OBSCN in paraffin-embedded Human skeletal muscle tissue by Immunohistochemistry.

Anti-OBSCN antibody (ab121652)参考文献

ab121652 has not yet been referenced specifically in any publications.

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