Anti-NUMBL抗体- N-terminal (ab80119)

概述

  • 产品名称Anti-NUMBL抗体- N-terminal
    参阅全部 NUMBL 一抗
  • 描述
    兔多克隆抗体to NUMBL - N-terminal
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH-conjugated synthetic peptide from the N-terminal region of Human NUMBL

  • 阳性对照
    • Human lung carcinoma tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Ammonium Sulphate Precipitation
  • 纯化说明Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab80119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/10 - 1/50.

靶标

  • 功能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 序列相似性Contains 1 PID domain.
  • 结构域The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 细胞定位Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAG 3A antibody
    • CAG3A antibody
    • CTG 3a antibody
    • CTG3a antibody
    • NBL antibody
    • NUMB Drosophilia Homolog Like antibody
    • Numb homolog (Drosophila) like antibody
    • Numb homolog like antibody
    • Numb like protein antibody
    • NUMB R antibody
    • Numb-like protein antibody
    • Numb-R antibody
    • Numb-related gene antibody
    • Numb-related protein antibody
    • NUMBL antibody
    • NUMBL_HUMAN antibody
    • NUMBLIKE antibody
    • NUMBR antibody
    • TNRC 23 antibody
    • TNRC23 antibody
    • Trinucleotide repeat-containing gene 23 antibody
    see all

Anti-NUMBL antibody - N-terminal 图像

  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue using 1/10 ab80122, in conjunction with a peroxidase-conjugated secondary antibody, followed by DAB staining.

Anti-NUMBL antibody - N-terminal (ab80119)参考文献

ab80119 has not yet been referenced specifically in any publications.

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