概述

  • 产品名称
  • 描述
    兔多克隆抗体to NUMBL
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 571-600 of Human NUMBL (NP_004747.1).

  • 阳性对照
    • 293 cell line lysates.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab116296 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.

靶标

  • 功能
    Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 序列相似性
    Contains 1 PID domain.
  • 结构域
    The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 细胞定位
    Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAG 3A antibody
    • CAG3A antibody
    • CTG 3a antibody
    • CTG3a antibody
    • NBL antibody
    • NUMB Drosophilia Homolog Like antibody
    • Numb homolog (Drosophila) like antibody
    • Numb homolog like antibody
    • Numb like protein antibody
    • NUMB R antibody
    • Numb-like protein antibody
    • Numb-R antibody
    • Numb-related gene antibody
    • Numb-related protein antibody
    • NUMBL antibody
    • NUMBL_HUMAN antibody
    • NUMBLIKE antibody
    • NUMBR antibody
    • TNRC 23 antibody
    • TNRC23 antibody
    • Trinucleotide repeat-containing gene 23 antibody
    see all

图片

  • Anti-NUMBL antibody (ab116296) at 1/100 dilution + 293 cell line lysates at 35 µg

    Predicted band size : 65 kDa

实验方案

文献

ab116296 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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