Anti-Nucleostemin抗体(ab14293)

概述

• 产品名称
  Anti-Nucleostemin抗体
  参阅全部 Nucleostemin 一抗
• 描述
  鸡多克隆抗体to Nucleostemin
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide corresponding to Human Nucleostemin aa 1-280.
  Sequence:

  MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKQGHKKPRKDPGV PNSAPFKEAL LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDI KPSNVEPMEKEFGLCKTENKAK SGKQNSKKLYCQELKKVIEASDVVLE VLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS DLVPKENLESWLNY LKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL WK LLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMC

  Run BLAST with Run BLAST with
• 常规说明
  During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgY
• 研究领域
  • Cell Biology
  • Apoptosis
  • Intracellular
  • Associated Proteins

  • Neuroscience
  • Cell Type Marker
  • Neural Stem Cell marker

  • Stem Cells
  • Embryonic Stem Cells
  • Intracellular

  • Stem Cells
  • Neural Stem Cells
  • Intracellular

  • Stem Cells
  • Mesenchymal Stem Cells
  • Intracellular

  • Developmental Biology
  • Embryogenesis
  • Embryonic stem cells
  • Surface molecules

应用

靶标

• 功能
  May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.
• 组织特异性
  Increased levels in lung tissue in cancer patients.
• 序列相似性
  Belongs to the MMR1/HSR1 GTP-binding protein family.
  Contains 1 G (guanine nucleotide-binding) domain.
• 结构域
  The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.
  In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
• 细胞定位
  Nucleus. Nucleus > nucleolus. Shuttles between the nucleus and nucleolus.

• Target information above from: UniProt accession Q9BVP2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 26354 Human
  • Entrez Gene: 30877 Mouse
  • Entrez Gene: 290556 Rat
  • Omim: 608011 Human
  • SwissProt: Q9BVP2 Human
  • SwissProt: Q8CI11 Mouse
  • SwissProt: Q811S9 Rat
  • Unigene: 313544 Human

  • Unigene: 88512 Mouse
  • Unigene: 4110 Rat

  see all
• 别名
  • C77032 antibody
  • E2 induced gene 3 protein antibody
  • E2-induced gene 3 protein antibody

  • E2IG3 antibody
  • Estradiol induced nucleotide binding protein antibody
  • GNL3 antibody
  • GNL3_HUMAN antibody
  • Guanine nucleotide binding protein like 3 (nucleolar) antibody
  • Guanine nucleotide binding protein like 3 antibody
  • Guanine nucleotide-binding protein-like 3 antibody
  • MGC800 antibody
  • NNP47 antibody
  • Novel nucleolar protein 47 antibody
  • NS antibody
  • Nucleolar GTP binding protein 3 antibody
  • Nucleolar GTP-binding protein 3 antibody
  • Nucleostemin antibody
  • Putative nucleotide binding protein estradiol induced antibody

  see all

实验方案

• Western blot protocols