Anti-Nuclear Matrix Protein p84抗体[3121C2a] (ab54370)


  • 产品名称Anti-Nuclear Matrix Protein p84抗体[3121C2a]
    参阅全部 Nuclear Matrix Protein p84 一抗
  • 描述
    小鼠单克隆抗体[3121C2a] to核Matrix Protein p84
  • 经测试应用适用于: WB, Dot Blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: QYLKGQVKFK SSNYVLTDEQ SLWIEDTTKS VYQLLSENPP DGERFSKMVE HILNTEENWN SWKNEGCPSF VKERTSDTKP TRIIRKRTAP EDFLGKGPTK , corresponding to internal sequence amino acids 330-437 of Human Nuclear Matrix Protein p84


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4)
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab54370 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
  • 克隆单克隆
  • 克隆编号3121C2a
  • 同种型IgG2b
  • 研究领域


Our Abpromise guarantee covers the use of ab54370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 76 kDa.
Dot Blot Use at an assay dependent dilution.


  • 功能Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
    Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
  • 组织特异性Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.
  • 序列相似性Contains 1 death domain.
  • 结构域An intact death domain is needed for apoptosis.
  • 翻译后修饰Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass.
  • 细胞定位Cytoplasm and Nucleus speckle. Nucleus > nucleoplasm. Nucleus matrix. Cytoplasm. Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
  • Information by UniProt
  • 数据库链接
  • 形式Nuclear (Isoform 1) and Cytoplasmic (Isoform 1 and 2).
  • 别名
    • hTREX84 antibody
    • Death domain containing protein p84N5 antibody
    • HPR 1 antibody
    • HPR1 antibody
    • hTREX84 antibody
    • Nuclear matrix protein p84 antibody
    • P84 antibody
    • p84N5 antibody
    • Tho 1 antibody
    • THO complex 1 antibody
    • THO complex subunit 1 antibody
    • Tho1 antibody
    • THOC 1 antibody
    • Thoc1 antibody
    • THOC1_HUMAN antibody
    see all

Anti-Nuclear Matrix Protein p84 antibody [3121C2a] 图像

Anti-Nuclear Matrix Protein p84 antibody [3121C2a] (ab54370)参考文献

ab54370 has not yet been referenced specifically in any publications.

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