概述

  • 产品名称
    Anti-NUAK2抗体
    参阅全部 NUAK2 一抗
  • 描述
    兔多克隆抗体to NUAK2
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant protein from Human NUAK2 (NP_112214.1).

  • 阳性对照
    • NIH 3T3 cell lysate, NCI-H292 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab107287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 70 kDa.

靶标

  • 功能
    Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
  • 序列相似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Information by UniProt
  • 数据库链接
    • 形式
      Involved in actin cytoskeleton organization.
    • 别名
      • DKFZp434J037 antibody
      • DKFZp686F01113 antibody
      • FLJ90349 antibody
      • NUAK family SNF1 like kinase 2 antibody
      • NUAK family SNF1-like kinase 2 antibody
      • Nuak2 antibody
      • NUAK2_HUMAN antibody
      • Omphalocele kinase 2 antibody
      • SNARK antibody
      • SNF1/AMP activated protein kinase antibody
      • SNF1/AMP kinase related kinase antibody
      • SNF1/AMP kinase-related kinase antibody
      see all

    图片

    • Western blot - NUAK2 antibody (ab107287)
      Western blot - NUAK2 antibody (ab107287)
      Anti-NUAK2 antibody (ab107287) at 1/100 dilution + NIH 3T3 cell lysate at 35 µg

      Predicted band size: 70 kDa

    • Western blot - Anti-NUAK2 antibody (ab107287)
      Western blot - Anti-NUAK2 antibody (ab107287)
      Anti-NUAK2 antibody (ab107287) at 1/100 dilution + NCI-H292 cell lysate at 35 µg

      Predicted band size: 70 kDa

    实验方案

    文献

    This product has been referenced in:
    • Tang L  et al. Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells. Exp Ther Med 13:676-680 (2017). Read more (PubMed: 28352350) »
    • Fu TG  et al. miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma. Int J Mol Med 37:1627-35 (2016). WB, IF ; Human . Read more (PubMed: 27081712) »

    See all 3 Publications for this product

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