Anti-NTAL抗体[NAP-07] (Phycoerythrin) (ab27574)

概述

  • 产品名称Anti-NTAL抗体[NAP-07] (Phycoerythrin)
    参阅全部 NTAL 一抗
  • 描述
    小鼠单克隆抗体[NAP-07] to NTAL (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment: cytoplasmic domain, amino acids 91-244 of human NTAL.

性能

应用

Our Abpromise guarantee covers the use of ab27574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/30.

靶标

  • 功能Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • 组织特异性Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • 疾病相关Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 翻译后修饰Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • 细胞定位Cell membrane. Present in lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HSPC046 antibody
    • LAB antibody
    • LAT2 antibody
    • Linker for activation of B cells antibody
    • Linker for activation of B-cells antibody
    • Linker for activation of T cells family member 2 antibody
    • Linker for activation of T cells transmembrane adaptor 2 antibody
    • Linker for activation of T-cells family member 2 antibody
    • Membrane associated adapter molecule antibody
    • Membrane-associated adapter molecule antibody
    • Non T cell activation linker antibody
    • Non-T-cell activation linker antibody
    • NTAL_HUMAN antibody
    • WBSCR 5 antibody
    • Wbscr15 antibody
    • Williams Beuren syndrome chromosome region 15 antibody
    • Williams Beuren syndrome chromosome region 5 antibody
    • Williams-Beuren syndrome chromosomal region 15 protein antibody
    • Williams-Beuren syndrome chromosomal region 5 protein antibody
    • WSCR5 antibody
    see all

Anti-NTAL antibody [NAP-07] (Phycoerythrin) (ab27574)参考文献

ab27574 has not yet been referenced specifically in any publications.

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