概述

  • 产品名称Anti-NTAL抗体
    参阅全部 NTAL 一抗
  • 描述
    兔多克隆抗体to NTAL
  • 特异性We have data to indicate that this antibody may not cross react with Human. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant fragment, corresponding to amino acids 30-229 of Mouse NTAL

  • 阳性对照
    • Mouse spleen.
  • 常规说明


    This antibody reacts with mouse NTAL (25 kDa) but not human.

性能

应用

Our Abpromise guarantee covers the use of ab36452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Use under non reducing condition. Detects a band of approximately 25 kDa.

靶标

  • 功能Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • 组织特异性Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • 疾病相关Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 翻译后修饰Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • 细胞定位Cell membrane. Present in lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HSPC046 antibody
    • LAB antibody
    • LAT2 antibody
    • Linker for activation of B cells antibody
    • Linker for activation of B-cells antibody
    • Linker for activation of T cells family member 2 antibody
    • Linker for activation of T cells transmembrane adaptor 2 antibody
    • Linker for activation of T-cells family member 2 antibody
    • Membrane associated adapter molecule antibody
    • Membrane-associated adapter molecule antibody
    • Non T cell activation linker antibody
    • Non-T-cell activation linker antibody
    • NTAL_HUMAN antibody
    • WBSCR 5 antibody
    • Wbscr15 antibody
    • Williams Beuren syndrome chromosome region 15 antibody
    • Williams Beuren syndrome chromosome region 5 antibody
    • Williams-Beuren syndrome chromosomal region 15 protein antibody
    • Williams-Beuren syndrome chromosomal region 5 protein antibody
    • WSCR5 antibody
    see all

Anti-NTAL antibody 图像

  • All lanes : Anti-NTAL antibody (ab36452) at 1 µg/ml

    Lane 1 : Mouse spleen tissue immunostained with rabbit polyclonal antibody to mouse Non-T cell Activation Linker (ab36452)
    Lane 2 : Mouse spleen tissue immunostained with rabbit polyclonal antibody to mouse Non-T cell Activation Linker, N-terminal.
    Lane 3 : Negative control


    Performed under non-reducing conditions.

    Observed band size : 25 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa (possible non-specific binding),75 kDa (possible non-specific binding),80 kDa (possible non-specific binding).

Anti-NTAL antibody (ab36452)参考文献

ab36452 has not yet been referenced specifically in any publications.

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