Anti-NRG1抗体[7D5] (Biotin) (ab79201)


  • 产品名称Anti-NRG1抗体[7D5] (Biotin)
    参阅全部 NRG1 一抗
  • 描述
    小鼠单克隆抗体[7D5] to NRG1 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant extracellular domain of rat NRG1 protein.

  • 阳性对照
    • NRG1 alpha1 or NRG1 beta1 recombinant protein. Prostate carcinoma.
  • 常规说明

    ab79201 does not inhibit the binding of NRG1 to ErbB receptors.



Our Abpromise guarantee covers the use of ab79201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 32 kDa.

Use for 2 hours at room temperature.

IP Use at 2 µg/mg of lysate.

Use Protein A.

IHC-P 1/25 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use for 60 minutes at room temperature. Boil tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes and use of a high sensitivity detection system.


  • 功能Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
  • 组织特异性Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.
  • 疾病相关Note=A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'-end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
  • 序列相似性Belongs to the neuregulin family.
    Contains 1 EGF-like domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 发展阶段Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain.
  • 结构域The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
    ERBB receptor binding is elicited entirely by the EGF-like domain.
  • 翻译后修饰Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
    N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage.
  • 细胞定位Secreted; Cell membrane. Does not seem to be active; Membrane. May possess an internal uncleaved signal sequence; Nucleus. May be nuclear and Secreted. Has a signal peptide.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor-inducing activity antibody
    • Acetylcholine receptor-inducing activity, CHICK, homolog of antibody
    • ARIA antibody
    • Breast cancer cell differentiation factor p45 antibody
    • GGF antibody
    • GGF2 antibody
    • Glial growth factor antibody
    • Heregulin antibody
    • heregulin, alpha (45kD, ERBB2 p185-activator) antibody
    • HGL antibody
    • HRG antibody
    • HRG1 antibody
    • HRGA antibody
    • MST131 antibody
    • NDF antibody
    • Neu differentiation factor antibody
    • Neuregulin 1 antibody
    • neuregulin 1 type IV beta 1a antibody
    • neuregulin 1 type IV beta 3 antibody
    • Neuregulin-1 antibody
    • NRG 1 antibody
    • nrg1 antibody
    • NRG1-IT2 antibody
    • NRG1_HUMAN antibody
    • OTTHUMP00000225398 antibody
    • OTTHUMP00000225419 antibody
    • OTTHUMP00000225420 antibody
    • OTTHUMP00000225421 antibody
    • OTTHUMP00000225422 antibody
    • OTTHUMP00000225477 antibody
    • OTTHUMP00000225545 antibody
    • OTTHUMP00000230603 antibody
    • OTTHUMP00000230605 antibody
    • pro-neuregulin-1, membrane-bound isoform antibody
    • Pro-NRG1 antibody
    • ProNRG1 antibody
    • Sensory and motor neuron-derived factor antibody
    • SMDF antibody
    see all

Anti-NRG1 antibody [7D5] (Biotin) (ab79201)参考文献

ab79201 has not yet been referenced specifically in any publications.

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