Anti-Nrf2抗体, prediluted (ab31164)

概述

  • 产品名称Anti-Nrf2抗体, prediluted
    参阅全部 Nrf2 一抗
  • 描述
    兔多克隆抗体to Nrf2, prediluted
  • 特异性ab31164 recognises Nrf2 protein.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide:

    TL YLEVFSMLRD EDGKPYSPS

    , corresponding to amino acids 569-588 of Human Nrf2

  • 阳性对照
    • Placenta

相关产品

应用

Our Abpromise guarantee covers the use of ab31164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: use neat for 30 min at RT. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol, by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
    • 组织特异性Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
    • 序列相似性Belongs to the bZIP family. CNC subfamily.
      Contains 1 bZIP domain.
    • 结构域Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.
    • 翻译后修饰Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
    • 细胞定位Cytoplasm > cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
    • Information by UniProt
    • 数据库链接
    • 别名
      • erythroid derived 2 antibody
      • HEBP1 antibody
      • like 2 antibody
      • NF E2 related factor 2 antibody
      • NF-E2-related factor 2 antibody
      • NF2L2_HUMAN antibody
      • NFE2 related factor 2 antibody
      • NFE2-related factor 2 antibody
      • Nfe2l2 antibody
      • Nrf 2 antibody
      • NRF2 antibody
      • Nuclear factor (erythroid derived 2) like 2 antibody
      • Nuclear factor antibody
      • nuclear factor erythroid 2 like 2 antibody
      • Nuclear factor erythroid 2 related factor 2 antibody
      • Nuclear factor erythroid 2-related factor 2 antibody
      • Nuclear factor erythroid derived 2 like 2 antibody
      see all

    Anti-Nrf2 antibody, prediluted 图像

    • Human placenta stained with anti-Nrf2 (ab31164, pre-diluted)

    Anti-Nrf2 antibody, prediluted (ab31164)参考文献

    ab31164 has not yet been referenced specifically in any publications.

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