Anti-NRAS抗体[AT2G9] (ab113627)

概述

  • 产品名称Anti-NRAS抗体[AT2G9]
    参阅全部 NRAS 一抗
  • 描述
    小鼠单克隆抗体[AT2G9] to NRAS
  • 特异性ab113627 recognises HRAS, NRAS and KRAS.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-186 of Human NRAS purified from E. coli (NP_002515).

  • 阳性对照
    • Recombinant NRAS, KRAS and HRAS, 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab113627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/5000. Predicted molecular weight: 21 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • 疾病相关Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.
    Defects in NRAS are the cause of Noonan syndrome type 6 (NS6) [MIM:613224]. A syndrome characterized by facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable intellectual deficits.
  • 序列相似性Belongs to the small GTPase superfamily. Ras family.
  • 翻译后修饰Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
  • 细胞定位Cell membrane. Golgi apparatus membrane. Shuttles between the plasma membrane and the Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALPS4 antibody
    • AV095280 antibody
    • GTPase NRas antibody
    • HRAS1 antibody
    • N ras antibody
    • N ras protein part 4 antibody
    • Neuroblastoma RAS viral (v ras) oncogene homolog antibody
    • NRAS antibody
    • NRAS1 antibody
    • NS6 antibody
    • OTTHUMP00000013879 antibody
    • OTTMUSP00000023521 antibody
    • RASN_HUMAN antibody
    • Transforming protein N Ras antibody
    • Transforming protein N-Ras antibody
    • v ras neuroblastoma RAS viral oncogene homolog antibody
    see all

Anti-NRAS antibody [AT2G9] 图像

  • Lane 1 : Anti-NRAS antibody [AT2G9] (ab113627) at 1/500 dilution
    Lane 2 : Anti-NRAS antibody [AT2G9] (ab113627) at 1/1000 dilution
    Lane 3 : Anti-NRAS antibody [AT2G9] (ab113627) at 1/5000 dilution

    Lane 1 : 293T cell lysate
    Lane 2 : 293T cell lysate
    Lane 3 : 293T cell lysate

    Lysates/proteins at 35 µg per lane.

    Secondary
    goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 21 kDa
  • All lanes : Anti-NRAS antibody [AT2G9] (ab113627) at 1/500 dilution

    Lane 1 : recombinant NRAS
    Lane 2 : recombinant KRAS
    Lane 3 : recombinant HRAS

    Lysates/proteins at 0.2 µg per lane.


    Predicted band size : 21 kDa

Anti-NRAS antibody [AT2G9] (ab113627)参考文献

ab113627 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113627.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"