概述

  • 产品名称Anti-NR2C2抗体
    参阅全部 NR2C2 一抗
  • 描述
    小鼠单克隆抗体to NR2C2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 43-153 of Human NR2C2

性能

应用

Our Abpromise guarantee covers the use of ab58365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml.
IHC-P Use a concentration of 3 µg/ml.

靶标

  • 功能Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 发展阶段Transiently repressed during the meiotic phase of spermatogenesis.
  • 翻译后修饰Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the nonphosphorylated form preferentially recruits the coactivator, PCAF.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 形式There are 2 isoforms produced by alternative splicing.
  • 别名
    • hTAK1 antibody
    • Nr2c2 antibody
    • NR2C2_HUMAN antibody
    • Nuclear hormone receptor TR4 antibody
    • Nuclear receptor subfamily 2 group C member 2 antibody
    • Orphan nuclear receptor TAK1 antibody
    • Orphan nuclear receptor TR4 antibody
    • TAK1 antibody
    • Testicular nuclear receptor 4 antibody
    • Testicular receptor 4 antibody
    • TR2R1 antibody
    • TR4 antibody
    • TR4 nuclear hormone receptor antibody
    see all

Anti-NR2C2 antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab58365 NR2C2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
  • ab58365 at 3 ug/ml staining NR2C2 in human esophagus tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded tissue sections).

Anti-NR2C2 antibody (ab58365)参考文献

ab58365 has not yet been referenced specifically in any publications.

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