功能Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
组织特异性Liver. Low levels of expression were detected in heart and pancreas.
序列相似性Belongs to the nuclear hormone receptor family. NR0 subfamily.
翻译后修饰Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
细胞定位Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
Immunohistochemical analysis of paraffin-embedded SW480 Xenograft, using ab96605 at 1:100 dilution.
Anti-NR0B2 antibody (ab96605)参考文献
This product has been referenced in:
Prestin K et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther9:4867-78 (2016).
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