概述

  • 产品名称Anti-NOXO1抗体
    参阅全部 NOXO1 一抗
  • 描述
    山羊多克隆抗体to NOXO1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    RGCVDSVPHPTTEQ

    , corresponding to C terminal amino acids 363-376 of Human NOXO1

  • 阳性对照
    • Human kidney tissue
  • 常规说明


    This antibody is expected to recognise all three reported isoforms.

性能

应用

Our Abpromise guarantee covers the use of ab77092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
  • 组织特异性Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 序列相似性Contains 1 PX (phox homology) domain.
    Contains 2 SH3 domains.
  • 发展阶段Isoform 3 is expressed in fetal liver.
  • 结构域The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
    The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.
  • 细胞定位Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
  • Information by UniProt
  • 数据库链接
  • 别名
    • NADPH oxidase organizer 1 antibody
    • NADPH oxidase regulatory protein antibody
    • Nox organizer 1 antibody
    • Nox organizing protein 1 antibody
    • Nox-organizing protein 1 antibody
    • NOXO1 antibody
    • NOXO1_HUMAN antibody
    • P41NOX antibody
    • Regulatory protein P41NOX antibody
    • SH3 and PX domain-containing protein 5 antibody
    • SH3PXD5 antibody
    see all

Anti-NOXO1 antibody 图像

  • Immunohistochemical analysis of paraffin embedded human kidney labelled with ab77092 at 10 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-NOXO1 antibody (ab77092)参考文献

ab77092 has not yet been referenced specifically in any publications.

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