功能Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
组织特异性Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
序列相似性Belongs to the NCF2/NOXA1 family. Contains 1 OPR domain. Contains 1 SH3 domain. Contains 4 TPR repeats.
发展阶段Expressed in fetal kidney.
结构域The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. The TPR repeats mediate interaction with RAC1.
翻译后修饰Interaction with YWHAZ depends on phosphorylation by PKA.
细胞定位Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.