Anti-NOR1/TEC抗体(ab94507)
Key features and details
- Rabbit polyclonal to NOR1/TEC
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-NOR1/TEC抗体
参阅全部 NOR1/TEC 一抗 -
描述
兔多克隆抗体to NOR1/TEC -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: IHC-P -
种属反应性
与反应: Mouse
预测可用于: Rat, Human, Pig -
免疫原
Synthetic peptide corresponding to Human NOR1/TEC aa 200-300 conjugated to keyhole limpet haemocyanin.
(Peptide available asab107791) -
阳性对照
- This antibody gave a positive signal in NIH3T3 whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab94507于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 µg/ml. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
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说明 |
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WB
Use a concentration of 1 µg/ml. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa). |
靶标
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功能
Binds to the B1A response-element. -
组织特异性
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta. -
疾病相关
Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. -
序列相似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 8013 Human
- Entrez Gene: 18124 Mouse
- Entrez Gene: 397479 Pig
- Entrez Gene: 58853 Rat
- Omim: 600542 Human
- SwissProt: Q92570 Human
- SwissProt: Q9QZB6 Mouse
- SwissProt: P51179 Rat
see all -
别名
- CHN antibody
- Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
- CSMF antibody
see all
图片
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Anti-NOR1/TEC antibody (ab94507) at 1 µg/ml + NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate at 10 µg
Secondary
Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 68 kDa
Observed band size: 68 kDa
Exposure time: 20 minutes
数据表及文件
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SDS download
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Datasheet download
文献 (7)
ab94507 被引用在 7 文献中.
- Lee JH et al. Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity. J Obes Metab Syndr 30:44-54 (2021). PubMed: 33518534
- Ma C et al. The pro-inflammatory effect of NR4A3 in osteoarthritis. J Cell Mol Med 24:930-940 (2020). PubMed: 31701670
- Chen H et al. miR-106b-5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells. Int J Mol Med 45:1525-1533 (2020). PubMed: 32323756
- Tan C et al. NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Nat Immunol 21:1267-1279 (2020). PubMed: 32868928
- Ozair MZ et al. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate. Cell Stem Cell 23:60-73.e6 (2018). PubMed: 29937203
- Nagaoka M et al. The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol 199:2958-2967 (2017). PubMed: 28893954
- Brunjes PC & Osterberg SK Developmental Markers Expressed in Neocortical Layers Are Differentially Exhibited in Olfactory Cortex. PLoS One 10:e0138541 (2015). PubMed: 26407299