概述

  • 产品名称
  • 描述
    小鼠单克隆抗体to NOR1
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 414-522 of Human NOR1

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

性能

应用

Our Abpromise guarantee covers the use of ab56340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 68 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能
    Binds to the B1A response-element.
  • 组织特异性
    Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
  • 疾病相关
    Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
    Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR4 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CHN antibody
    • Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
    • CSMF antibody
    • MINOR antibody
    • Mitogen induced nuclear orphan receptor antibody
    • Mitogen-induced nuclear orphan receptor antibody
    • Neuron derived orphan receptor 1 antibody
    • Neuron derived orphan receptor antibody
    • Neuron-derived orphan receptor 1 antibody
    • NOR1 antibody
    • Nr4a3 antibody
    • NR4A3_HUMAN antibody
    • Nuclear hormone receptor NOR-1 antibody
    • Nuclear hormone receptor NOR1 antibody
    • Nuclear receptor subfamily 4 group A member 3 antibody
    • TEC antibody
    • Translocated in extraskeletal chondrosarcoma antibody
    see all

图片

  • ab56340 at 10µg/ml, staining NOR1 in HeLa cells by Immunocytochemistry/immunofluorescense.

文献

This product has been referenced in:
  • Ogawa D  et al. Nuclear hormone receptor expression in mouse kidney and renal cell lines. PLoS One 9:e85594 (2014). ICC/IF ; Mouse . Read more (PubMed: 24465611) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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