概述

  • 产品名称Anti-NOP10抗体
    参阅全部 NOP10 一抗
  • 描述
    兔多克隆抗体to NOP10
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 1-50 (MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK) of Human NOLA3 (NP_061118).

  • 阳性对照
    • Jurkat cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 8 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 疾病相关Defects in NOP10 are a cause of dyskeratosis congenita autosomal recessive (ARDKC) [MIM:224230]. ARDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
  • 序列相似性Belongs to the NOP10 family.
  • 细胞定位Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKCB1 antibody
    • H/ACA ribonucleoprotein complex subunit 3 antibody
    • homolog of yeast Nop10p antibody
    • MGC70651 antibody
    • NOLA3 antibody
    • NOP10 antibody
    • NOP10 ribonucleoprotein homolog (yeast) antibody
    • NOP10_HUMAN antibody
    • NOP10P antibody
    • Nucleolar protein 10 antibody
    • Nucleolar protein family A member 3 antibody
    • nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody
    • snoRNP protein NOP10 antibody
    see all

Anti-NOP10 antibody 图像

  • Anti-NOP10 antibody (ab99084) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 8 kDa

Anti-NOP10 antibody (ab99084)参考文献

ab99084 has not yet been referenced specifically in any publications.

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