概述

  • 产品名称Anti-Nogo抗体
    参阅全部 Nogo 一抗
  • 描述
    兔多克隆抗体to Nogo
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 81-130 (RAYLESEVAI SEELVQKYSN SALGHVNCTI KELRRLFLVD DLVDSLKFAV) of Human Nogo (NP_008939).

  • 阳性对照
    • Human fetal muscle lysate.

性能

应用

Our Abpromise guarantee covers the use of ab105707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
  • 组织特异性Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
  • 序列相似性Contains 1 reticulon domain.
  • 结构域Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor.
  • 细胞定位Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110020G17Rik antibody
    • AA407876 antibody
    • AA409940 antibody
    • AA960376 antibody
    • ASY antibody
    • C130026I10Rik antibody
    • Foocen antibody
    • Glut4 vesicle 20 kDa protein antibody
    • Human NogoA antibody
    • Kiaa0886 antibody
    • KIAA4153 antibody
    • MGC116054 antibody
    • MGC139261 antibody
    • mKIAA0886 antibody
    • mKIAA4153 antibody
    • My043 protein antibody
    • Nbla00271 antibody
    • Nbla10545 antibody
    • Neurite growth inhibitor 220 antibody
    • Neurite Growth Inhibitor 220, included antibody
    • Neurite outgrowth inhibitor antibody
    • Neuroendocrine-specific protein antibody
    • Neuroendocrine-specific protein C homolog antibody
    • NI-250 antibody
    • NI220/250 antibody
    • Nogo A antibody
    • NOGO antibody
    • Nogo B antibody
    • Nogo C antibody
    • Nogo protein antibody
    • NOGOC antibody
    • NSP antibody
    • NSP-CL antibody
    • rat N antibody
    • Reticulon 4 antibody
    • Reticulon 5 antibody
    • Reticulon-4 antibody
    • Reticulon-5 antibody
    • RTN X antibody
    • RTN-x antibody
    • Rtn4 antibody
    • Rtn4 reticulon 4 antibody
    • RTN4-A antibody
    • RTN4-B1 antibody
    • RTN4-B2 antibody
    • RTN4-C antibody
    • RTN4_HUMAN antibody
    • Vp20 antibody
    see all

Anti-Nogo antibody 图像

  • Anti-Nogo antibody (ab105707) at 0.25 µg/ml + Human fetal muscle lysate at 10 µg

    Predicted band size : 22 kDa

Anti-Nogo antibody (ab105707)参考文献

ab105707 has not yet been referenced specifically in any publications.

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