Anti-Nociceptin抗体(ab10276)

概述

  • 产品名称Anti-Nociceptin抗体
    参阅全部 Nociceptin 一抗
  • 描述
    豚鼠多克隆抗体to Nociceptin
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Non Human Primates
  • 免疫原

    Synthetic peptide:

    FGGFTGARKSARKLANQ

    , corresponding to amino acids 122-138 of Rat prepronociceptin, the precurser to nociceptin.

性能

应用

Our Abpromise guarantee covers the use of ab10276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/500.

靶标

  • 功能Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • 组织特异性Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • 序列相似性Belongs to the opioid neuropeptide precursor family.
  • 翻译后修饰Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • N/OFQ antibody
    • N23K antibody
    • N23K/N27K antibody
    • Nociceptin, included antibody
    • nocistatin antibody
    • Npnc1 antibody
    • OFQ antibody
    • OFQ/N antibody
    • Orphanin FQ antibody
    • Orphanin FQ2 antibody
    • Pnoc antibody
    • PNOC_HUMAN antibody
    • ppN/OFQ antibody
    • PPNOC antibody
    • pre-pro-N/OFQ antibody
    • prepronociceptin antibody
    • pronociceptin antibody
    • Propronociceptin antibody
    see all

Anti-Nociceptin antibody 图像

  • ab10276 at 1/500 dilution staining  Nociceptin in paraventricular nucleus by Immunohistochemistry.

Anti-Nociceptin antibody (ab10276)参考文献

ab10276 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (Adult Brain, 40 micron, floating)
Specification Adult Brain, 40 micron, floating
Fixative Perfuse 4% Paraformaldehyde
Permeabilization Yes - .25% Triton,
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C
Username

Dr. Joseph Dougherty

Verified customer

提交于 Aug 08 2007

Thank you for your enquiry. Below are the main differences between these two antibodies. Ab10276 - Guinea pig polyclonal to Nociceptin - was generated using the following inmmunogen: Synthetic peptide: FGGFTGARKSARKLANQ, corresponding to amino acids...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"