概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab5891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 2310005C01Rik
    • BNOS
    • Constitutive NOS
    • EC 1.14.13.39
    • IHPS 1
    • IHPS1
    • N-NOS
    • NC-NOS
    • neuronal Nitric Oxide Synthase
    • Neuronal NOS
    • Nitric oxide synthase , neuronal, included
    • Nitric oxide synthase 1
    • Nitric oxide synthase 1 (neuronal)
    • Nitric oxide synthase, brain
    • Nitric oxide synthase, penile neuronal, included
    • NNOS
    • NO
    • NOS
    • NOS 1
    • NOS type I
    • NOS-I
    • NOS1
    • NOS1_HUMAN
    • Peptidyl-cysteine S-nitrosylase NOS1
    see all
  • 功能Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
  • 组织特异性Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
  • 序列相似性Belongs to the NOS family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.
    Contains 1 PDZ (DHR) domain.
  • 结构域The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14.
  • 翻译后修饰Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
  • 细胞定位Cell membrane > sarcolemma. Cell projection > dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
  • Information by UniProt

nNOS (neuronal) peptide (ab5891)参考文献

ab5891 has not yet been referenced specifically in any publications.

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