Anti-nNOS (neuronal)抗体(ab79051)

概述

• 产品名称Anti-nNOS (neuronal)抗体
  参阅全部 nNOS (neuronal) 一抗
• 描述
  兔多克隆抗体to nNOS (neuronal)
• 经测试应用适用于: WB, IP, IHC-P, ICCmore details
• 种属反应性
  与反应: Rat, Human
  预测可用于: Mouse, Rabbit
• 免疫原

  Synthetic peptide:

  ESKKDTDEVFSS

  , corresponding to amino acids 1422-1433 of Human nNOS (neuronal)
  Run BLAST with Run BLAST with
• 阳性对照
  • Skeletal muscle tissue.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液pH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: 50% Glycerol, Tris buffered saline
• Concentration information loading...
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Neuroscience
  • Neurotransmission
  • Nitric Oxide
  • NOS

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Skeletal muscle (human) normal tissue slides (ab4366)

应用

靶标

• 功能Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
• 组织特异性Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
• 序列相似性Belongs to the NOS family.
  Contains 1 FAD-binding FR-type domain.
  Contains 1 flavodoxin-like domain.
  Contains 1 PDZ (DHR) domain.
• 结构域The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14.
• 翻译后修饰Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
• 细胞定位Cell membrane > sarcolemma. Cell projection > dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.

• Target information above from: UniProt accession P29475 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 4842 Human
  • Entrez Gene: 18125 Mouse
  • Entrez Gene: 100009243 Rabbit
  • Entrez Gene: 24598 Rat
  • Omim: 163731 Human
  • SwissProt: P29475 Human
  • SwissProt: Q9Z0J4 Mouse
  • SwissProt: O19132 Rabbit

  • SwissProt: P29476 Rat
  • Unigene: 654410 Human
  • Unigene: 684465 Human
  • Unigene: 684466 Human
  • Unigene: 684467 Human
  • Unigene: 442195 Mouse
  • Unigene: 44249 Mouse
  • Unigene: 10573 Rat

  see all
• 别名
  • 2310005C01Rik antibody
  • BNOS antibody
  • Constitutive NOS antibody

  • EC 1.14.13.39 antibody
  • IHPS 1 antibody
  • IHPS1 antibody
  • N-NOS antibody
  • NC-NOS antibody
  • neuronal Nitric Oxide Synthase antibody
  • Neuronal NOS antibody
  • Nitric oxide synthase , neuronal, included antibody
  • Nitric oxide synthase 1 (neuronal) antibody
  • Nitric oxide synthase 1 antibody
  • Nitric oxide synthase, brain antibody
  • Nitric oxide synthase, penile neuronal, included antibody
  • NNOS antibody
  • NO antibody
  • NOS 1 antibody
  • NOS antibody
  • NOS type I antibody
  • NOS-I antibody
  • NOS1 antibody
  • NOS1_HUMAN antibody
  • Peptidyl-cysteine S-nitrosylase NOS1 antibody

  see all