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功能
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
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组织特异性
Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
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序列相似性
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
Contains 1 PDZ (DHR) domain.
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结构域
The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14.
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翻译后修饰
Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
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细胞定位
Cell membrane > sarcolemma. Cell projection > dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
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Information by UniProt
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数据库链接
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别名
- 2310005C01Rik antibody
- BNOS antibody
- Constitutive NOS antibody
- EC 1.14.13.39 antibody
- IHPS 1 antibody
- IHPS1 antibody
- N-NOS antibody
- NC-NOS antibody
- neuronal Nitric Oxide Synthase antibody
- Neuronal NOS antibody
- Nitric oxide synthase , neuronal, included antibody
- Nitric oxide synthase 1 (neuronal) antibody
- Nitric oxide synthase 1 antibody
- Nitric oxide synthase, brain antibody
- Nitric oxide synthase, penile neuronal, included antibody
- NNOS antibody
- NO antibody
- NOS 1 antibody
- NOS antibody
- NOS type I antibody
- NOS-I antibody
- NOS1 antibody
- NOS1_HUMAN antibody
- Peptidyl-cysteine S-nitrosylase NOS1 antibody
see all