概述

  • 产品名称Anti-NMRAL1抗体
    参阅全部 NMRAL1 一抗
  • 描述
    兔多克隆抗体to NMRAL1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 11-60 (GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD) of Mouse NMRAL1 (NP_080669)

  • 阳性对照
    • Mouse heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab105801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
  • 序列相似性Belongs to the NmrA-type oxidoreductase family.
  • 细胞定位Cytoplasm. Cytoplasm > perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ25918 antibody
    • HSCARG antibody
    • NmrA like family domain containing 1 antibody
    • NmrA like family domain containing protein 1 antibody
    • NmrA-like family domain-containing protein 1 antibody
    • NMRAL1 antibody
    • NMRL1_HUMAN antibody
    • SDR48A1 antibody
    see all

Anti-NMRAL1 antibody 图像

  • Anti-NMRAL1 antibody (ab105801) at 1 µg/ml + Mouse heart lysate at 10 µg

    Predicted band size : 33 kDa

Anti-NMRAL1 antibody (ab105801)参考文献

ab105801 has not yet been referenced specifically in any publications.

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