概述

  • 产品名称Anti-NMNAT3抗体
    参阅全部 NMNAT3 一抗
  • 描述
    山羊多克隆抗体to NMNAT3
  • 特异性ab123807 is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Dog
  • 免疫原

    Synthetic peptide:

    C-QHNIHLAKEPVQNE

    , corresponding to internal sequence amino acids 149-162 of Human NMNAT3 isoform 2 and 186-199 of Human NMNAT3 isoform 1 (NP_001186976.1. NP_835471.1).

  • 阳性对照
    • Human kidney lysate.

性能

应用

Our Abpromise guarantee covers the use of ab123807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 24 kDa).

靶标

  • 功能Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
  • 组织特异性Expressed in lung and spleen with lower levels in placenta and kidney.
  • 通路Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
  • 序列相似性Belongs to the eukaryotic NMN adenylyltransferase family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • NaMN adenylyltransferase 3 antibody
    • Nicotinamide mononucleotide adenylyltransferase 3 antibody
    • Nicotinamide nucleotide adenylyltransferase 3 antibody
    • Nicotinate-nucleotide adenylyltransferase 3 antibody
    • NMN adenylyltransferase 3 antibody
    • NMNA3_HUMAN antibody
    • NMNAT 3 antibody
    • Nmnat3 antibody
    • PNAT 3 antibody
    • PNAT-3 antibody
    • PNAT3 antibody
    • Pyridine nucleotide adenylyltransferase 3 antibody
    see all

Anti-NMNAT3 antibody 图像

  • Anti-NMNAT3 antibody (ab123807) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 24 kDa

Anti-NMNAT3 antibody (ab123807)参考文献

ab123807 has not yet been referenced specifically in any publications.

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