概述

  • 产品名称Anti-NMDAR2C抗体
    参阅全部 NMDAR2C 一抗
  • 描述
    兔多克隆抗体to NMDAR2C
  • 特异性ab110 labels the 140 kDa band representing NR2C in Western blots of cerebellum. It also labels the 180 kDa NR2A and NR2B bands in hippocampus. Immunolabeling is blocked by preadsorption of the antibody with the immunogen.
  • 经测试应用适用于: WB, IPmore details
    不适用于: IHC-Fr
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Fusion protein corresponding to Rat NMDAR2C aa 25-130 (N terminal).
    Database link: Q14957

  • 常规说明

    ab110 can be used to demonstrate that the NMDAR2C is highly enriched in the cerebellum.

性能

应用

Our Abpromise guarantee covers the use of ab110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 140 kDa.
IP Use at an assay dependent concentration.

3 µl will quantitatively immunoprecipitate all NMDAR2C in 200 µg of rat cerebellum.

  • 应用说明Is unsuitable for IHC-Fr.
  • 靶标

    • 功能NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
    • 组织特异性Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
    • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
    • 细胞定位Cell membrane. Cell junction, synapse, postsynaptic cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • GluN2C antibody
      • Glutamate [NMDA] receptor subunit epsilon-3 antibody
      • Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody
      • Glutamate receptor ionotropic, NMDA 2C antibody
      • Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody
      • Grin2c antibody
      • N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody
      • N Methyl D Aspartate Receptor Subtype 2C antibody
      • N methyl D aspartate receptor subunit 2C antibody
      • N-methyl D-aspartate receptor subtype 2C antibody
      • NMDAR2C antibody
      • NMDE3_HUMAN antibody
      • NR2C antibody
      • OTTHUMP00000041930 antibody
      see all

    Anti-NMDAR2C antibody 图像

    • Anti-NMDAR2C antibody (ab110) at 1/1000 dilution + Rat cerebellar lysate

      Predicted band size : 140 kDa
      Observed band size : 140 kDa

      Specific staining of the ~140k R2C subunit of the receptor.

    Anti-NMDAR2C antibody (ab110)参考文献

    This product has been referenced in:
    • Buret L & van den Buuse M Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia. Int J Neuropsychopharmacol 17:1221-32 (2014). WB ; Mouse . Read more (PubMed: 24556017) »
    • Pristerà A  et al. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiol Aging 34:2551-63 (2013). Read more (PubMed: 23769395) »

    See all 6 Publications for this product

    Product Wall

    I have received confirmation from the laboratory that this Anti-NMDAR2C antibody has not been tested in IHC on paraffin-embedded tissue. It is possible it will work but I expect it will require heat-mediated antigen retrieval and tests of various antib...

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    Thank you for your enquiry. I am sorry that Ab110 did not work properly for you. Since you used it in a tested application with a species this antibody is known to cross-react with, this should have worked. If you would like to share further d...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"