概述

  • 产品名称Anti-NLRX1抗体
    参阅全部 NLRX1 一抗
  • 描述
    兔多克隆抗体to NLRX1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow, Dog
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 900 to the C-terminus of Human NLRX1.

  • 阳性对照
    • This antibody gave a positive signal in the following lysates: MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate; HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate; THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab91659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 mg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 108 kDa).

靶标

  • 功能Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
  • 组织特异性Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
  • 序列相似性Belongs to the NLRP family.
    Contains 7 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 细胞定位Mitochondrion outer membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Caterpiller protein 11.3 antibody
    • CLR11.3 antibody
    • DLNB26 antibody
    • FLJ21478 antibody
    • MGC131937 antibody
    • MGC21025 antibody
    • NLR family member X1 antibody
    • NLR family, X1 antibody
    • Nlrx1 antibody
    • NLRX1_HUMAN antibody
    • NOD-like receptor X1 antibody
    • NOD26 antibody
    • NOD5 antibody
    • NOD9 antibody
    • Nucleotide-binding oligomerization domain protein 26 antibody
    • Nucleotide-binding oligomerization domain protein 5 antibody
    • Nucleotide-binding oligomerization domain protein 9 antibody
    • nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody
    • Protein Caterpiller 11.3 antibody
    see all

Anti-NLRX1 antibody 图像

  • All lanes : Anti-NLRX1 antibody (ab91659) at 1 µg/ml

    Lane 1 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate
    Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 3 : THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 108 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 60 kDa,75 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 4 minutes

Anti-NLRX1 antibody (ab91659)参考文献

ab91659 has not yet been referenced specifically in any publications.

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