Anti-NLRX1抗体(ab105412)
Key features and details
- Rabbit polyclonal to NLRX1
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-NLRX1抗体
参阅全部 NLRX1 一抗 -
描述
兔多克隆抗体to NLRX1 -
宿主
Rabbit -
特异性
At least two isoforms of NLRX1 are known to exist; ab105412 will recognize both. This antibody is predicted to not crossreact with other NLRP family members. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Rat -
免疫原
A 14 amino acid peptide near the amino terminus of Human NLRX1 (NP_078894).
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阳性对照
- Rat spleen tissue lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105412于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF |
Use a concentration of 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa.
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IHC-P |
Use a concentration of 10 µg/ml.
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说明 |
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ICC/IF
Use a concentration of 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa. |
IHC-P
Use a concentration of 10 µg/ml. |
靶标
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功能
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). -
组织特异性
Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level). -
序列相似性
Belongs to the NLRP family.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
细胞定位
Mitochondrion outer membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 315599 Rat
- SwissProt: Q5FVQ8 Rat
- Unigene: 12444 Rat
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别名
- Caterpiller protein 11.3 antibody
- CLR11.3 antibody
- DLNB26 antibody
see all
图片
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Immunofluorescence of NLRX1 in rat spleen tissue with ab105412 at 20 ug/mL.
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Lane 1 : Anti-NLRX1 antibody (ab105412) at 1 µg/ml
Lane 2 : Anti-NLRX1 antibody (ab105412) at 2 µg/ml
All lanes : rat spleen tissue cell lysate
Predicted band size: 108 kDa -
Immunohistochemistry of NLRX1 in rat spleen tissue with ab105412 at 10 µg/ml.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab105412 被引用在 3 文献中.
- He B et al. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury. Aging (Albany NY) 13:8127-8145 (2021). PubMed: 33686956
- Peng L et al. DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke. J Neuroinflammation 17:81 (2020). PubMed: 32151250
- Luo X et al. HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. J Clin Invest 130:1635-1652 (2020). PubMed: 31874109