Anti-NLRP7抗体(ab117732)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to NLRP7
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the N-terminus of Human NLRP7.

  • 阳性对照
    • Human Spleen tissue

性能

应用

Our Abpromise guarantee covers the use of ab117732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 111 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能
    Inhibits CASP1/caspase-1-dependent IL1B secretion.
  • 组织特异性
    Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
  • 疾病相关
    Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
  • 序列相似性
    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLR19.4 antibody
    • FLJ94610 antibody
    • HYDM antibody
    • MGC126470 antibody
    • MGC126471 antibody
    • NACHT, leucine rich repeat and PYD containing 7 antibody
    • NACHT, LRR and PYD containing protein 7 antibody
    • NACHT, LRR and PYD domains containing protein 7 antibody
    • NACHT, LRR and PYD domains-containing protein 7 antibody
    • NALP7 antibody
    • NALP7_HUMAN antibody
    • NLR family, pyrin domain containing 7 antibody
    • NLRP7 antibody
    • NOD12 antibody
    • Nucleotide-binding oligomerization domain protein 12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7 antibody
    • PAN7 antibody
    • PYPAF3 antibody
    • PYRIN-containing APAF1-like protein 3 antibody
    see all

Anti-NLRP7 antibody 图像

  • ab117732 at 5 µg/ml staining NLRP7 in Formalin-Fixed, Paraffin-Embedded Human Spleen.

Anti-NLRP7 antibody (ab117732)参考文献

ab117732 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Western blot
Sample
Human Cell lysate - whole cell (Hhuman Peripheral Blood Mononuclear Cells)
Gel Running Conditions
Reduced Denaturing
Loading amount
20 µg
Treatment
10 ug/ml azithromycin
Specification
Hhuman Peripheral Blood Mononuclear Cells
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
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提交于 Apr 26 2017

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