概述

  • 产品名称Anti-NLK抗体
    参阅全部 NLK 一抗
  • 描述
    兔多克隆抗体to NLK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 407-436 of Human NLK (NP_032728.3)

  • 阳性对照
    • MCF7 cell line and Mouse lung tissue lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab116715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 58 kDa.

靶标

  • 功能Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Dually phosphorylated on Thr-303 and Tyr-305, which activates the enzyme.
  • 细胞定位Nucleus. Cytoplasm. Predominantly nuclear. A smaller fraction is cytoplasmic.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp761G1211 antibody
    • FLJ21033 antibody
    • LAK1 antibody
    • Nemo like kinase antibody
    • Nemo-like kinase antibody
    • Nlk antibody
    • NLK_HUMAN antibody
    • Protein LAK1 antibody
    • Serine/threonine protein kinase NLK antibody
    • Serine/threonine-protein kinase NLK antibody
    see all

Anti-NLK antibody 图像

  • Anti-NLK antibody (ab116715) at 1/100 dilution + MCF7 cell line lysate at 35 µg

    Predicted band size : 58 kDa
  • Anti-NLK antibody (ab116715) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

    Predicted band size : 58 kDa

Anti-NLK antibody (ab116715)参考文献

ab116715 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116715.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"