概述

  • 产品名称Anti-nkx6.1抗体
    参阅全部 nkx6.1 一抗
  • 描述
    兔多克隆抗体to nkx6.1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2 - 51 (LAVGAMEGTR QSAFLLSSPP LAALHSMAEM KTPLYPAAYP PLPAGPPSSS) of Human nkx6.1 (NP_006159).

  • 阳性对照
    • Human fetal small intestine lysate

性能

应用

Our Abpromise guarantee covers the use of ab90706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
  • 组织特异性Pancreatic beta cells.
  • 序列相似性Contains 1 homeobox DNA-binding domain.
  • 结构域The C-terminal domain contributes to sequence-specific DNA-binding.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Homeobox protein NK-6 homolog A antibody
    • Homeobox protein Nkx-6.1 antibody
    • NK homeo box, family 6, member A antibody
    • NK homeobox (Drosophila), family 6, A antibody
    • NK homeobox, family 6, A antibody
    • NK6 homeobox 1 antibody
    • NK6 transcription factor homolog A antibody
    • NK6 transcription factor related, locus 1 antibody
    • NK6 transcription factor related, locus 1 (Drosophila) antibody
    • NKX6-1 antibody
    • NKX6.1 antibody
    • NKX61 antibody
    • NKX61_HUMAN antibody
    • NKX6A antibody
    see all

Anti-nkx6.1 antibody 图像

  • Anti-nkx6.1 antibody (ab90706) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal small intestine lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa

Anti-nkx6.1 antibody (ab90706)参考文献

This product has been referenced in:
  • Wheeler E  et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet 45:513-7 (2013). Human . Read more (PubMed: 23563609) »

See 1 Publication for this product

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