功能Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
组织特异性Pancreatic beta cells.
序列相似性Contains 1 homeobox DNA-binding domain.
结构域The C-terminal domain contributes to sequence-specific DNA-binding.