概述

  • 产品名称Anti-NKIRAS1抗体
    参阅全部 NKIRAS1 一抗
  • 描述
    兔多克隆抗体to NKIRAS1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36 - 85 (CETMEDVYMA SVETDRGVKE QLHLYDTRGL QEGVELPKHY FSFADGFVLV) of Human NKIRAS1 (NP_065078)

  • 阳性对照
    • Jurkat cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab83872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 mg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • 结构域In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2400004O09Rik antibody
    • I kappa B interacting Ras like protein 1 antibody
    • I-kappa-B-interacting Ras-like protein 1 antibody
    • Kappa B Ras 1 antibody
    • Kappa B Ras protein 1 antibody
    • Kappa B-Ras protein 1 antibody
    • KappaB Ras1 antibody
    • KappaB-Ras1 antibody
    • KBRAS 1 antibody
    • KBRAS1 antibody
    • KBRS1_HUMAN antibody
    • NF kappa B inhibitor interacting Ras like protein 1 antibody
    • NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody
    • NFKB inhibitor interacting Ras like 1 antibody
    • NFKB inhibitor interacting Ras like protein 1 antibody
    • NKIRAS 1 antibody
    • nkiras1 antibody
    see all

Anti-NKIRAS1 antibody 图像

  • Anti-NKIRAS1 antibody (ab83872) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 22 kDa
    Observed band size : 26 kDa (why is the actual band size different from the predicted?)

Anti-NKIRAS1 antibody (ab83872)参考文献

ab83872 has not yet been referenced specifically in any publications.

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