Anti-NKIRAS1抗体[184C278] (ab13666)

概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号184C278
  • 同种型IgG1
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab13666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 23 kDa.

靶标

  • 功能Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • 结构域In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2400004O09Rik antibody
    • I kappa B interacting Ras like protein 1 antibody
    • I-kappa-B-interacting Ras-like protein 1 antibody
    • Kappa B Ras 1 antibody
    • Kappa B Ras protein 1 antibody
    • Kappa B-Ras protein 1 antibody
    • KappaB Ras1 antibody
    • KappaB-Ras1 antibody
    • KBRAS 1 antibody
    • KBRAS1 antibody
    • KBRS1_HUMAN antibody
    • NF kappa B inhibitor interacting Ras like protein 1 antibody
    • NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody
    • NFKB inhibitor interacting Ras like 1 antibody
    • NFKB inhibitor interacting Ras like protein 1 antibody
    • NKIRAS 1 antibody
    • nkiras1 antibody
    see all

Anti-NKIRAS1 antibody [184C278] (ab13666)参考文献

ab13666 has not yet been referenced specifically in any publications.

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